Reacción #8679

Ecuación de reacción

tert-butyl (3S,4S)-3,4-dimethoxy-1-pyrrolidinecarboxylate

tert-Butyl (3S,4S)-3,4-dimethoxy-1-pyrrolidinecarboxylate

→

(3S,4S)-3,4-Dimethoxypyrrolidine

Disolventes

hydrochloric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent is removed in vacuo
2. 2
   workup.ADDITIONmixed with 1N sodium hydroxide solution
3. 3
   workup.STIRRINGstirred at RT for 10 minutes
4. 4
   OtroThe phases are separated
5. 5
   Extracciónthe aqueous phase is extracted several times with DCM
6. 6
   ExtracciónThe combined organic phases are extracted with saturated aqueous sodium chloride solution
7. 7
   Otrodried
8. 8
   Filtraciónfiltered
9. 9
   Otrothe solvent is removed in vacuo
10. 10
    Otro872 mg (63% of theory) of the product are obtained

Procedimiento

2.30 g (9.35 mmol; 94% pure) of tert-butyl (3S,4S)-3,4-dimethoxy-1-pyrrolidinecarboxylate (example XVI, step 2) are taken up in 50 ml of hydrochloric acid (4M in dioxane) and stirred at RT overnight. The solvent is removed in vacuo, and the residue is suspended in DCM, mixed with 1N sodium hydroxide solution and stirred at RT for 10 minutes. The phases are separated and the aqueous phase is extracted several times with DCM. The combined organic phases are extracted with saturated aqueous sodium chloride solution, dried and filtered, and the solvent is removed in vacuo. 872 mg (63% of theory) of the product are obtained.

Fuente