Reacción #8678

Ecuación de reacción

1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide

diethyl 2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)malonate

Diethyl 2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)malonate

→

2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(8-oxa-3-azabicyclo-[3.2.1]oct-3-yl)-4,6-pyrimidinediol

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe solid is then filtered off with suction
2. 2
   Lavadowashed with diethyl ether
3. 3
   Otrodried in vacuo

Procedimiento

0.50 g (1.11 mmol) of 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide (example I, step 5) are suspended in 40 ml of toluene. Then 1.40 g (5.16 mmol) of diethyl 2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)malonate from step 5 are added. The mixture is stirred at 140° C. overnight. The solid is then filtered off with suction, washed with diethyl ether dried in vacuo.

Fuente