Reacción #86460

Ecuación de reacción

Thionyl chloride

4-amino-3-nitrobenzoic acid

methanol

→

title compound

Rendimiento 100.0%

methyl 4-amino-3-nitrobenzoate

Rendimiento 100.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe resulting mixture was then refluxed for 12 h
2. 2
   OtroThe yellow solid precipitated
3. 3
   Filtraciónwas filtered
4. 4
   Otrodried

Procedimiento

Thionyl chloride (19.4 g, 164.85 mmol) was added to a solution of 4-amino-3-nitrobenzoic acid (20 g, 109.89 mmol) in methanol (200 mL) at 0° C. The resulting mixture was then refluxed for 12 h. The reaction mixture was allowed to cool to room temperature. The yellow solid precipitated was filtered and dried to afford the title compound (22 g, yield: 100%) as a solid. 1H-NMR (CDCl3, 300 MHz): δ 8.85 (d, 1H), 7.99 (dd, 1H), 6.83 (d, 1H), 6.40 (s, 2H), 3.90 (s, 3H).

Fuente