Reacción #86307

Ecuación de reacción

N-benzoyl-D,L-isoleucyl-L-proline benzyl ester

hydrogen

→

N-benzoyl-D,L-isoleucyl-L-proline

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto react at room temperature for 3 h
2. 2
   Filtraciónfiltered
3. 3
   Concentraciónconcentrated under reduced pressure
4. 4
   Otroto remove the solvent
5. 5
   Otroto give a colourless sticky matter (1.04 g, 99%), which
6. 6
   Otrowas directly used for the next reaction

Procedimiento

N-benzoyl-D,L-isoleucyl-L-proline benzyl ester (1.1 g) was dissolved in methanol (15 ml), and 10% palladium-carbon (120 mg) was added. The resulting mixture aerated with hydrogen was allowed to react at room temperature for 3 h, filtered and concentrated under reduced pressure to remove the solvent to give a colourless sticky matter (1.04 g, 99%), which was directly used for the next reaction.

Fuente