Reacción #86242

Ecuación de reacción

2-bromo-6-fluoropyridine

1,4-diazepan-6-ol

DIPEA

→

1-(6-Bromopyridin-2-yl)-1,4-diazepan-6-ol

Disolventes

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter completion of the reaction, it
2. 2
   Concentraciónwas concentrated under reduced pressure
3. 3
   OtroThe crude material was used in the next step without further purification

Procedimiento

To a mixture of 2-bromo-6-fluoropyridine (845 mg, 4.83 mmol) and 1,4-diazepan-6-ol (560 mg, 4.83 mmol) in EtOH (20 mL) was added DIPEA (5 mL). The reaction mixture was heated at 100° C. for 15 hours, which was monitored by LCMS. After completion of the reaction, it was concentrated under reduced pressure. The crude material was used in the next step without further purification. MS (ESI) m/z: 272 [M+H]+.

Fuente