Reacción #86223

Ecuación de reacción

1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1,4-diazepan-6-ol

2-bromo-6-fluoropyridine

6-chloro-1H-pyrazolo[4,3-c]pyridine

→

solid

Rendimiento 23.5%

(S)-1-(6-(6-(1-Methyl-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-1,4-diazepan-6-ol

Rendimiento 23.5%

Condiciones de reacción

Procedimiento

Following the procedures as described in Example 124 and starting with 1,4-diazepan-6-ol, 2-bromo-6-fluoropyridine, 6-chloro-1H-pyrazolo[4,3-c]pyridine, and 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 231 was obtained as a yellow solid (43 mg, 23.5%) over six steps. 1H NMR (500 MHz, DMSO-d6) δ (ppm) 9.09 (s, 1H), 8.65 (s, 1H), 8.44 (s, 1H), 8.25 (s, 1H), 7.98 (s, 1H), 7.63-7.68 (m, 1H), 7.14-7.16 (d, J=12.5 Hz, 1H), 6.61-6.64 (d, J=14 Hz, 1H), 4.10-4.14 (m, 1H), 3.86-3.91 (m, 6H), 3.55-3.66 (m, 2H), 2.98-3.04 (m, 3H), 2.84-2.90 (m, 1H), 2.69-2.71 (m, 1H); MS (ESI) m/z: 391 [M+H]+.

Fuente