Reacción #86175

Ecuación de reacción

2-bromo-6-fluoropyridine

1,4-diazepan-6-ol

DIPEA

→

1-(6-bromopyridin-2-yl)-1,4-diazepan-6-ol

Rendimiento 54.4%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter it was cooled
2. 2
   Concentraciónthe reaction mixture was concentrated under reduced pressure
3. 3
   workup.ADDITIONThe residue was diluted with EtOAc (100 mL)
4. 4
   Lavadowashed with brine
5. 5
   SecadoThe organic layer was dried over Na2SO4
6. 6
   Concentraciónconcentrated under reduced pressure

Procedimiento

A mixture of 2-bromo-6-fluoropyridine (477 mg, 2.7 mmol), 1,4-diazepan-6-ol (350 mg, 3 mmol), and DIPEA (1.94 g, 15 mmol) in ethanol (10 mL) was heated at 100° C. for 16 hours. After it was cooled, the reaction mixture was concentrated under reduced pressure. The residue was diluted with EtOAc (100 mL) and washed with brine. The organic layer was dried over Na2SO4 and concentrated under reduced pressure to afford 1-(6-bromopyridin-2-yl)-1,4-diazepan-6-ol as a colorless oil (400 mg, 48.9%). MS (ESI) m/z: 272 [M+H]+.

Fuente