Reacción #85903

Ecuación de reacción

methyl 3-aminopropanoate hydrochloride

Et3N

5,7-dichloropyrido[4,3-b]pyrazine

→

title compound

methyl 3-(7-chloropyrido[4,3-b]pyrazin-5-ylamino)propanoate

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroVolatiles were removed under reduced pressure
2. 2
   workup.ADDITIONthe residue was treated with water
3. 3
   Extracciónextracted with EtOAc
4. 4
   SecadoThe combined extracts were dried over Na2SO4
5. 5
   Filtraciónfiltered
6. 6
   Concentraciónconcentrated
7. 7
   OtroThe residue was purified by chromatography

Procedimiento

A solution of methyl 3-aminopropanoate hydrochloride (4.88 mmol), Et3N (6.50 mmol) and 5,7-dichloropyrido[4,3-b]pyrazine (3.25 mmol) in THF (10 mL) was stirred at room temperature overnight. Volatiles were removed under reduced pressure, and the residue was treated with water and extracted with EtOAc. The combined extracts were dried over Na2SO4, filtered, and concentrated. The residue was purified by chromatography to afford the title compound. MS (m/z): 267 (M+H)+.

Fuente