Reacción #85902

ord-ed0564b52aa7489a890b56a40958687a

Ecuación de reacción

C[C@H](O)C1CCN(c2nc(Cl)cc3nccnc23)C1
(S)-1-(1-(7-chloropyrido[4,3-b]pyrazin-5-yl)pyrrolidin-3-yl)ethanol
OB(O)c1ccc(N2CCOCC2)cc1
4-morpholinophenylboronic acid
→
C[C@H](O)C1CCN(c2nc(-c3ccc(N4CCOCC4)cc3)cc3nccnc23)C1
title compound
C[C@H](O)C1CCN(c2nc(-c3ccc(N4CCOCC4)cc3)cc3nccnc23)C1
(S)-1-(1-(7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yl)pyrrolidin-3-yl)ethanol

Reactantes

—
Compound 1
C[C@H](O)C1CCN(c2nc(Cl)cc3nccnc23)C1
(S)-1-(1-(7-chloropyrido[4,3-b]pyrazin-5-yl)pyrrolidin-3-yl)ethanol
OB(O)c1ccc(N2CCOCC2)cc1
4-morpholinophenylboronic acid

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared according to the procedure of Compound 1 (B) using (S)-1-(1-(7-chloropyrido[4,3-b]pyrazin-5-yl)pyrrolidin-3-yl)ethanol and 4-morpholinophenylboronic acid. MS (m/z): 406 (M+H)+.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09434726B2uspto-grants-2016_09