Reacción #85894

ord-e599baed4a414dda88e024d000d4e251

Ecuación de reacción

CC(C)(C)OC(=O)N1CC(O)CC(CNc2nc(Cl)cc3nccnc23)C1
tert-butyl 3-((7-chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)-5-hydroxypiperidine-1-carboxylate
OB(O)c1ccc(N2CCOCC2)cc1
4-morpholinophenylboronic acid
→
CC(C)(C)OC(=O)N1CC(O)CC(CNc2nc(-c3ccc(N4CCOCC4)cc3)cc3nccnc23)C1
title compound
CC(C)(C)OC(=O)N1CC(O)CC(CNc2nc(-c3ccc(N4CCOCC4)cc3)cc3nccnc23)C1
tert-butyl 3-hydroxy-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate

Reactantes

—
Compound 1
CC(C)(C)OC(=O)N1CC(O)CC(CNc2nc(Cl)cc3nccnc23)C1
tert-butyl 3-((7-chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)-5-hydroxypiperidine-1-carboxylate
OB(O)c1ccc(N2CCOCC2)cc1
4-morpholinophenylboronic acid

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared according to the procedures of Compound 1 (B) using tert-butyl 3-((7-chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)-5-hydroxypiperidine-1-carboxylate and 4-morpholinophenylboronic acid. MS (m/z): 521 (M+H)+.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09434726B2uspto-grants-2016_09