Reacción #85880

Ecuación de reacción

(S)-tert-butyl 3-((7-chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate

4-morpholinophenylboronic acid

Cs2CO3

→

title compound

Rendimiento 73.0%

(S)-tert-butyl 3-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate

Rendimiento 73.0%

Disolventes

dimethoxyethane ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas sealed in a microwave reaction
2. 2
   TemperaturaThe mixture was cooled to room temperature
3. 3
   Concentraciónconcentrated
4. 4
   Otropurified by chromatography

Procedimiento

A mixture of (S)-tert-butyl 3-((7-chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate (0.15 mmol), 4-morpholinophenylboronic acid (0.23 mmol), PdCl2 (dppf) (0.015 mmol) and Cs2CO3 (0.30 mmol) in dimethoxyethane/ethanol was sealed in a microwave reaction and stirred at 160° C. for 45 minutes in a microwave reactor. The mixture was cooled to room temperature, concentrated, and purified by chromatography to afford the title compound (73% yield). MS (m/z): 505 (M+H)+.

Fuente