Reacción #85876

Ecuación de reacción

2-chloro-N-(3-(dibenzylamino)-2-hydroxypropyl)acetamide

t-BuOK

→

6-((dibenzylamino)methyl)morpholin-3-one

Disolventes

t-BuOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux overnight
2. 2
   ConcentraciónAfter concentration
3. 3
   Otrothe residue was purified by column chromatography
4. 4
   Otroto give product as white solid

Procedimiento

A solution of 2-chloro-N-(3-(dibenzylamino)-2-hydroxypropyl)acetamide (1.0 g, 2.49 mmol), t-BuOK (0.39 g, 3.57 mmol) in t-BuOH (30 mL) was stirred at reflux overnight. After concentration, the residue was purified by column chromatography to give product as white solid.

Fuente