Reacción #85801

Ecuación de reacción

2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

methanamine

DIPEA

→

title compound

N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

Disolventes

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónIt was then concentrated under reduced pressure
2. 2
   workup.ADDITIONthe residue was treated in EtOAc
3. 3
   OtroThe insoluble solid was removed by filtration
4. 4
   Concentraciónthe organic solution was concentrated under reduced pressure

Procedimiento

A mixture of 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (200 mg, 0.84 mmol), methanamine (277 mg, 8.4 mmol), and DIPEA (0.35 mL, 2.01 mmol) in dioxane (5 mL) was stirred at room temperature for 16 hours. It was then concentrated under reduced pressure, and the residue was treated in EtOAc. The insoluble solid was removed by filtration, and the organic solution was concentrated under reduced pressure to give the title compound.

Fuente