Reacción #85721

Ecuación de reacción

(R)—N—((R)-1-(1-(4-chlorophenyl)-1H-pyrazol-3-yl)ethyl)-2-methylpropane-2-sulfinamide

HCl

→

product

Rendimiento 83.3%

(R)-1-(1-(4-chlorophenyl)-1H-pyrazol-3-yl)ethanamine

Rendimiento 83.3%

Disolventes

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated
2. 2
   workup.ADDITIONDCM (20 mL) and saturated NaHCO3 solution (10 mL) was added to the residue
3. 3
   workup.STIRRINGThe mixture was stirred for 10 minutes
4. 4
   Otrophases were separated
5. 5
   ExtracciónAqueous layer was then extracted with DCM (2×10 mL)
6. 6
   Secadothe combined organic was dried (Na2SO4)
7. 7
   Concentraciónconcentrated

Procedimiento

To a solution of (R)—N—((R)-1-(1-(4-chlorophenyl)-1H-pyrazol-3-yl)ethyl)-2-methylpropane-2-sulfinamide (0.98 g, 3.01 mmol) in dioxane (10 ml) was added dropwise HCl (1.504 ml, 6.01 mmol). The reaction was stirred at room temperature for 30 minutes. LCMS indicated complete conversion to product. The reaction mixture was concentrated and DCM (20 mL) and saturated NaHCO3 solution (10 mL) was added to the residue. The mixture was stirred for 10 minutes and phases were separated. Aqueous layer was then extracted with DCM (2×10 mL), and the combined organic was dried (Na2SO4) and concentrated to give product (0.556 g). LCMS (B) m/z 222.2 (M+H)+

Fuente