Reacción #85672

ord-3f40672f04234437b94cc209b747090f

Ecuación de reacción

C[C@H](NC(=O)OC(C)(C)C)c1ccc(C=O)c(F)c1
(S)-tert-butyl 1-(3-fluoro-4-formylphenyl)ethylcarbamate
Cl.FC1(F)CCNCC1
4,4-difluoropiperidine hydrochloride
[Al]
intermediate 111
[Al]
aluminum
→
C[C@H](NC(=O)OC(C)(C)C)c1ccc(CN2CCC(F)(F)CC2)c(F)c1
Title compound
C[C@H](NC(=O)OC(C)(C)C)c1ccc(CN2CCC(F)(F)CC2)c(F)c1
(S)-tert-butyl 1-(4-((4,4-difluoropiperidin-1-yl)methyl)-3-fluorophenyl)ethylcarbamate

Reactantes

C[C@H](NC(=O)OC(C)(C)C)c1ccc(C=O)c(F)c1
(S)-tert-butyl 1-(3-fluoro-4-formylphenyl)ethylcarbamate
Cl.FC1(F)CCNCC1
4,4-difluoropiperidine hydrochloride
[Al]
intermediate 111
[Al]
aluminum

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Following the procedure for intermediate 111: Title compound was prepared from (S)-tert-butyl 1-(3-fluoro-4-formylphenyl)ethylcarbamate and 4,4-difluoropiperidine hydrochloride as a white solid. LCMS tR=1.63 min; MS m/z 371.5 (M−H).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09434719B2uspto-grants-2016_09