Reacción #85515

Ecuación de reacción

Ammonium hydroxide

2-aminobenzenethiol

3-aminopyrazole-4-carbonitrile

→

title compound

Rendimiento 40.5%

4-Benzothiazol-2-yl-1H-pyrazol-3-ylamine

Rendimiento 40.5%

Disolventes

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe resulting yellow solid was isolated by filtration
2. 2
   Lavadowashed with cold water

Procedimiento

A mixture of 2-aminobenzenethiol (100 mg, 0.8 mmol) and 3-aminopyrazole-4-carbonitrile (86 mg, 0.8 mmol) in 3 g of polyphosphoric acid was heated at 200° C. for 3 hours. The mixture was then poured into ice water and was neutralized with conc. Ammonium hydroxide solution. The resulting yellow solid was isolated by filtration and washed with cold water to yield the title compound (70 mg, 40%). MS (m/z, ES+): 217 (M+1, 100%); 1H NMR (300 MHz, ppm, DMSO-d6): δ 7.97 (d, 3J=7.8 Hz, 1H), 7.88 (s, 1H), 7.84 (d, 3J=8.0 Hz, 1H), 7.42 (m, 1H), 7.29 (m, 1H), 6.3 (br s, 2H).

Fuente