Reacción #85503

Ecuación de reacción

(2-fluorophenyl)thiourea

bromine

→

title compound

Rendimiento 72.0%

4-Fluorobenzothiazol-2-ylamine

Rendimiento 72.0%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe resulting mixture was heated
2. 2
   Temperaturaunder reflux for 3 hrs
3. 3
   OtroThe solvent was evaporated
4. 4
   workup.ADDITIONwater was added
5. 5
   OtroThe resulting white precipitation
6. 6
   Filtraciónwas collected by filtration
7. 7
   Otrodried

Procedimiento

To a suspension of (2-fluorophenyl)thiourea (1.7 g, 10.0 mmol) in chloroform (25 ml) was added a solution of bromine (0.51 mL; 10.0 mmol) dropwise at room temperature. The resulting mixture was heated under reflux for 3 hrs. The solvent was evaporated, water was added and the mixture was neutralized with ammonium hydroxide. The resulting white precipitation was collected by filtration and dried to yield 1.2 g (72%) of the title compound which was used in the subsequent step without further purification.

Fuente