Reacción #8527

Ecuación de reacción

hydrogen

2,3,4-Trifluoroaniline

methyl pyruvate

magnesium sulfate

→

title compound

Rendimiento 95.3%

Methyl 2-(2,3,4-trifluoroanilino)propionate

Rendimiento 95.3%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónAfter filtering off Pd—C and magnesium sulfate
2. 2
   Concentraciónthe obtained filtrate was concentrated under reduced pressure
3. 3
   OtroThe crystals thus precipitated
4. 4
   Filtraciónwere filtered
5. 5
   Lavadowhile washing with hexane

Procedimiento

2,3,4-Trifluoroaniline (2.94 g) and methyl pyruvate (2.04 g) were dissolved in methanol (30 ml). After adding 5% Pd—C (2.0 g) and anhydrous magnesium sulfate (2.65 g), the mixture was stirred at 50° C. in a hydrogen atmosphere for 16 hours. After filtering off Pd—C and magnesium sulfate, the obtained filtrate was concentrated under reduced pressure. The crystals thus precipitated were filtered while washing with hexane. Thus the title compound (4.44 g) was obtained as slightly yellowish crystals. Various spectral data of this product was identical with those obtained in Example 5.

Fuente