Reacción #84887

Ecuación de reacción

tert-butyl 2-(2-fluoro-4-nitrobenzoyl)-2-methylhydrazinecarboxylate

→

2-Fluoro-N-methyl-4-nitrobenzohydrazide

Disolventes

hydrochloric acid dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated under reduced pressure
2. 2
   Lavadowashed with saturated aqueous sodium bicarbonate solution
3. 3
   SecadoThe organic phase was dried (sodium sulphate)
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated under reduced pressure

Procedimiento

A solution of 3.6 g (11.5 mmol) of tert-butyl 2-(2-fluoro-4-nitrobenzoyl)-2-methylhydrazinecarboxylate in 57 ml of 4-molar hydrochloric acid/dioxane solution was stirred at RT for 3 h. The reaction mixture was concentrated under reduced pressure and the residue was taken up in ethyl acetate and washed with saturated aqueous sodium bicarbonate solution. The organic phase was dried (sodium sulphate), filtered and concentrated under reduced pressure. Yield: 2.0 g (81% of theory)

Fuente