Reacción #84824

Ecuación de reacción

5-Bromo-2-(difluoromethoxy)-1,3-dimethoxybenzene

2-furylboronic acid

→

2-(4-(difluoromethoxy)-3,5-dimethoxyphenyl)furan

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofor the synthesis of Example 21
2. 2
   OtroPurification by chromatography (0-30% EtOAc-hexanes)

Procedimiento

5-Bromo-2-(difluoromethoxy)-1,3-dimethoxybenzene was coupled with 2-furylboronic acid following the procedure for the synthesis of Example 21. Purification by chromatography (0-30% EtOAc-hexanes) provided 2-(4-(difluoromethoxy)-3,5-dimethoxyphenyl)furan as a white crystalline material (0.555 g, 67% yield).

Fuente