Reacción #8481

Ecuación de reacción

epichlorohydrin

product

2-[4-hydroxyphenyl]-8-methylimidazo[1,2-a]pyridine

potassium hydroxide

→

title compound

2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

Disolventes

dichloromethane

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónfiltered
2. 2
   Lavadothe filtrate washed with water
3. 3
   Otrodried
4. 4
   Filtraciónsodium sulfate filtered
5. 5
   Otroevaporated

Procedimiento

The product of Step B (27 g) in methanol (500 mL) was treated with potassium hydroxide (14 g) and stirred at ambient temperature for 2 hours. To this solution was then added epichlorohydrin (9.4 mL) and the mixture stirred for an additional 48 hours. The reaction mixture was diluted with dichloromethane, filtered and the filtrate washed with water, dried, sodium sulfate filtered and evaporated to afford the title compound (18.2 g).

Fuente