Reacción #84754

Ecuación de reacción

(6-amino-3-bromo-2-fluorophenyl)methanol

→

title product

Rendimiento 73.0%

6-amino-3-bromo-2-fluorobenzaldehyde

Rendimiento 73.0%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe solid was filtered off
2. 2
   Concentraciónthe filtrate was concentrated

Procedimiento

A suspension mixture of (6-amino-3-bromo-2-fluorophenyl)methanol (8.3 g, 37.72 mmol) and manganese(IV) oxide (19.68 g, 226.32 mmol) in dichloromethane (400 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title product as a light yellow solid (6.0 g, 73%), which was directly used in the next step without further purification. MS (ES+) C7H5BrFNO requires: 217, found: 218, 220 [M+H]+.

Fuente