Reacción #8473

Ecuación de reacción

product

2-[4-Bromophenyl]-7-methylimidazo[1,2-a]pyridine

triethylamine

3-butyn-1-ol

→

title compound

Rendimiento 71.7%

2-[4-[4-Hydroxybut-1-ynyl]phenyl]-7-methylimidazo[1,2-a]pyridine

Rendimiento 71.7%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was cooled to ambient temperature
2. 2
   Temperaturaheated
3. 3
   Temperaturaat reflux temperature for 18 hours
4. 4
   TemperaturaThe mixture was cooled to ambient temperature
5. 5
   Otroevaporated to dryness
6. 6
   OtroThe residue was crystallized

Procedimiento

The product of Step A (1.8 g) in dry acetonitrile (40 mL) was treated sequentially with tetrakis(triphenylphosphine)palladium(0) (0.1 g), triethylamine (1.27 g), and CuI (10 mg) then heated at 60° C. for 30 minutes. The mixture was cooled to ambient temperature, treated with 3-butyn-1-ol (0.361 g) and heated at reflux temperature for 18 hours. The mixture was cooled to ambient temperature and evaporated to dryness. The residue was crystallized, twice, from acetone to afford the title compound (1.02 g).

Fuente