Reacción #84724

Ecuación de reacción

tert-butyl (2S,4S,5S)-5-azido-2-methyltetrahydro-2H-pyran-4-ylcarbamate

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title compound

Rendimiento 18.1%

tert-butyl (2S,4S,5S)-5-amino-2-methyltetrahydro-2H-pyran-4-ylcarbamate

Rendimiento 18.1%

Disolventes

isopropanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónAfter that, the mixture was filtered through a pad of celite
2. 2
   ConcentraciónConcentrated

Procedimiento

A mixture of tert-butyl (2S,4S,5S)-5-azido-2-methyltetrahydro-2H-pyran-4-ylcarbamate (1.8 g, 3.6 mmol) and 10% palladium on carbon (50 mg) in isopropanol (10 mL) was stirred at room temperature under hydrogenation overnight. After that, the mixture was filtered through a pad of celite. Concentrated to get the title compound (150 mg, crude) as a yellow oil, which was used directly for the next step without further purification.

Fuente