Reacción #8465

Ecuación de reacción

product

alpha-bromo-2′-methyl-4′-chloropropoxyacetophenone

2-amino-4-picoline

→

2-(4′-chloropropoxy-2′-methylphenyl)-7-methylimidazo[1,2-a]pyridine

Disolventes

ethanol

methanol dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe resin was removed via filtration
2. 2
   Otrothe filtrate evaporated
3. 3
   OtroThe title compound was precipitated from ethyl acetate upon addition of hexanes
4. 4
   Otroused without further purification

Procedimiento

A solution of the product of Step B (6.77 g) and 2-amino-4-picoline (2.4 g) in ethanol (22 mL) was heated at 72° C. for 10 hours. The reaction mixture was cooled to ambient temperature and dissolved in methanol/dichloromethane and treated with Dowex® 550A basic resin until the pH of the mixture was 7. The resin was removed via filtration and the filtrate evaporated. The title compound was precipitated from ethyl acetate upon addition of hexanes and used without further purification.

Fuente