Reacción #8464

Ecuación de reacción

sodium bicarbonate

product

2′-methyl-4′-chloropropoxyacetophenone

bromine

→

title compound

alpha-bromo-2′-methyl-4′-chloropropoxyacetophenone

Disolventes

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe organic layer was separated
2. 2
   LavadoThe aqueous layer was washed with a fresh portion of ether (100 mL)
3. 3
   LavadoThe combined organic layers were washed with a fresh portion of water (100 mL)
4. 4
   Secadodried over magnesium sulfate
5. 5
   Filtraciónfiltered
6. 6
   Otroevaporated

Procedimiento

A solution of the product of Step A (9.33 g) in ether (42 mL) was treated with bromine (2.1 mL) and the mixture stirred for approximately 17 hours. The mixture was slowly poured into saturated sodium bicarbonate solution (100 mL) and then the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (100 mL). The combined organic layers were washed with a fresh portion of water (100 mL), dried over magnesium sulfate, filtered and evaporated to give the title compound (11 g).

Fuente