Reacción #8450

Ecuación de reacción

p-hydroxyacetophenone

1-bromo-3-chloropropane

potassium carbonate

→

title compound

p-chloropropoxyacetophenone

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux temperature for 18 hours
2. 2
   Filtraciónfiltered
3. 3
   ConcentraciónThe filtrate was concentrated in vacuo
4. 4
   workup.DISSOLUTIONThe residue was dissolved in ether
5. 5
   Lavadowashed with water
6. 6
   Secadodried over sodium sulfate
7. 7
   Filtraciónfiltered
8. 8
   Otroevaporated

Procedimiento

A mixture of p-hydroxyacetophenone (15 g) and 1-bromo-3-chloropropane (12 mL) in acetone (200 mL) was treated with potassium carbonate (17 g). The mixture was stirred at reflux temperature for 18 hours. The reaction was cooled to ambient temperature and filtered. The filtrate was concentrated in vacuo. The residue was dissolved in ether, washed with water, dried over sodium sulfate, filtered and evaporated to yield the title compound (23 g).

Fuente