Reacción #84474

Ecuación de reacción

3-(3-fluoro-4-(piperazin-1-yl)phenyl)-2,6-dimethylpyrimidin-4(3H)-one

K2CO3

3-bromoprop-1-yne

→

title compound

Rendimiento 44.1%

3-(3-fluoro-4-(4-(prop-2-yn-1-yl)piperazin-1-yl)phenyl)-2,6-dimethylpyrimidin-4(3H)-one

Rendimiento 44.1%

Disolventes

CH3CN

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture was then filtered
2. 2
   Concentraciónthe filtrate was concentrated in vacuo
3. 3
   OtroThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)

Procedimiento

To a suspension of 3-(3-fluoro-4-(piperazin-1-yl)phenyl)-2,6-dimethylpyrimidin-4(3H)-one (0.30 g, 1.00 mmol) and K2CO3 (0.69 g, 5.00 mmol) in CH3CN (15 mL) was added 3-bromoprop-1-yne (0.12 g, 1.01 mmol) and the mixture was stirred at rt for 36 h. The mixture was then filtered, and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid (0.15 g, 44%). The compound was characterized by the following spectroscopic data:

Fuente