Reacción #84406

Ecuación de reacción

1,2-difluoro-4-nitrobenzene

K2CO3

pyrrole

→

title compound

Rendimiento 97.0%

1-(2-fluoro-4-nitrophenyl)-1H-pyrrole

Rendimiento 97.0%

Disolventes

DMSO

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled to rt
2. 2
   Filtraciónfiltered
3. 3
   Otrothe filter cake was dried

Procedimiento

To a solution of 1,2-difluoro-4-nitrobenzene (1.59 g, 10 mmol) in DMSO (15 mL) were added K2CO3 (3.04 g, 22 mmol) and pyrrole (0.74 g, 11 mmol) with stirring. The reaction mixture was heated at 90° C. for 18 h, and cooled to rt. The mixture was diluted with water (50 mL), filtered and the filter cake was dried to give the title compound as a yellow solid (2.00 g, 97%).

Fuente