Reacción #84400

Ecuación de reacción

tert-butyl (3-morpholinophenyl)carbamate

HCl

→

title compound

Rendimiento 91.0%

3-morpholinoaniline

Rendimiento 91.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water (100 mL)
3. 3
   Extracciónextracted with CH2Cl2 (100 mL×3)
4. 4
   LavadoThe combined organic phases were washed with brine (150 mL)
5. 5
   Secadodried over anhydrous Na2SO4
6. 6
   Concentraciónconcentrated in vacuo

Procedimiento

A solution of tert-butyl (3-morpholinophenyl)carbamate (5.91 g, 21.20 mmol) in a solution of HCl (106 mL, 106.0 mmol, 1 M in MeOH) was stirred at rt overnight, then concentrated in vacuo. The residue was dissolved in water (100 mL). The soltution was basified with saturated Na2CO3 aqueous solution and extracted with CH2Cl2 (100 mL×3). The combined organic phases were washed with brine (150 mL), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a light brown solid (3.42 g, 91%).

Fuente