Reacción #84174

Ecuación de reacción

Compound 64

6-Acetyl-3-chloro-pyridine-2-carbonitrile

N,N-dimethylformamide dimethyl acetal

→

compound 67

Rendimiento 35.0%

3-Chloro-6-(−3-dimethylamino-acryloyl)-pyridine-2-carbonitrile

Rendimiento 35.0%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato reflux for 5 h
2. 2
   OtroAfter which time the solvent was evaporated
3. 3
   Otrothe crude product triturated with isoxane/diethylether

Procedimiento

Compound 64 (633 mg, 2.7 mmol) and N,N-dimethylformamide dimethyl acetal (1.1 mL, 8.1 mmol) in toluene was heated to reflux for 5 h. After which time the solvent was evaporated and the crude product triturated with isoxane/diethylether to give compound 67 as an orange solid (222 mg, 35%); LCMS Rt=2.35 min (MeOH-FA method), m/z 236 (MH+).

Fuente