Reacción #84050

Ecuación de reacción

pentafluorophenol

EDC

1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride

→

Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe contents of the flask are concentrated in vacuo
2. 2
   Otrodried under high vacuum
3. 3
   OtroThe resulting crude product is employed without further purification in the following stages

Procedimiento

358 mg (1.94 mmol) of pentafluorophenol, 120.5 mg (0.63 mmol) of EDC and 1 drop of N,N-diisopropylethylamine are added to a solution of 100 mg (0.49 mmol) of 1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride in 4 ml of dichloromethane at 0° C. The mixture is stirred at room temperature for 18 h. The contents of the flask are concentrated in vacuo and dried under high vacuum. The resulting crude product is employed without further purification in the following stages.

Fuente