Reacción #84048

Ecuación de reacción

quinuclidin-3-one hydrochloride

sodium methoxide

→

title compound

Quinuclidin-3-one

Disolventes

methanol

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe resulting precipitate is filtered off with suction
2. 2
   Concentraciónthe filtrate is concentrated in vacuo
3. 3
   OtroThe residue is partitioned between chloroform and water
4. 4
   Extracciónextracted with chloroform
5. 5
   SecadoThe combined organic phases are dried over sodium sulfate
6. 6
   Concentraciónconcentrated in vacuo

Procedimiento

100 g (0.62 mol) of quinuclidin-3-one hydrochloride are suspended in 2 l of methanol. At 0° C., a solution of 33.4 g (0.62 mol) of sodium methoxide in 250 ml of methanol is slowly added dropwise. The mixture is stirred at room temperature for 16 h. The resulting precipitate is filtered off with suction, and the filtrate is concentrated in vacuo. The residue is partitioned between chloroform and water and extracted with chloroform. The combined organic phases are dried over sodium sulfate and concentrated in vacuo. 58.8 g (75.9% of theory) of the title compound are obtained.

Fuente