Reacción #8390

Ecuación de reacción

NaOH

4-(2-furyl)-1-(3-nitrobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine

SnCl2.2H2O

→

title compound

Rendimiento 115.9%

1-(3-Aminobenzyl)-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine

Rendimiento 115.9%

Disolventes

EtOH

HCl

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathen heated at 70° C. for 2 h
2. 2
   TemperaturaThe reaction mixture was cooled
3. 3
   Filtraciónfiltered
4. 4
   workup.ADDITIONtreated with HCl in dioxan (4-M, 2 mL)
5. 5
   workup.ADDITIONdiluted with diethyl ether
6. 6
   Filtraciónfiltered

Procedimiento

A suspension of 4-(2-furyl)-1-(3-nitrobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine (396 mg, 1.18 mmol) in EtOH (5 mL) was heated to 50° C., treated with a solution of SnCl2.2H2O (798 mg, 3.54 mmol) in conc. HCl (1.8 mL), stirred at 50° C. for 2 h then heated at 70° C. for 2 h. The reaction mixture was cooled, basified (5-M NaOH) filtered and the resulting solid suspended in MeOH, treated with HCl in dioxan (4-M, 2 mL), diluted with diethyl ether and filtered to give the title compound (419 mg, 94%) as a yellow solid.

Fuente