Reacción #83852

Ecuación de reacción

6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole

K2CO3

3-(2-methoxyphenoxy)propyl chloride

fumaric acid

→

6-fluoro-3-[1-[3-(2-methoxyphenoxy)-propyl]-4-piperidinyl]-1,2-benzisoxazole fumarate

Disolventes

acetonitrile

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAt the end of the reaction
2. 2
   Otrothe solvent was removed
3. 3
   workup.DISSOLUTIONthe solids were dissolved into dichloromethane (100 ml)
4. 4
   LavadoThe solution was washed with water and brine
5. 5
   Secadodried over MgSO4
6. 6
   Otroprepared in the same fashion (using 0.5 g of starting material)
7. 7
   OtroThe combined material was purified by flash chromatography on a silica gel column (49 g, eluted with 0.5% diethylamine: 1% methanol:98.5% dichloromethane, 1 L)
8. 8
   workup.ADDITIONThe fractions containing the pure product
9. 9
   Concentraciónconcentrated down to a light oil (3.68 g)

Procedimiento

A stirred mixture of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole (2.45 g; 11.1 mmol), K2CO3 (2.0 g), and 3-(2-methoxyphenoxy)propyl chloride (3.5 g, 17.4 mmol) in acetonitrile (40 ml) was heated at 90° C. for 4 hours. At the end of the reaction, the solvent was removed, and the solids were dissolved into dichloromethane (100 ml). The solution was washed with water and brine, then dried over MgSO4. The crude material from the solution was combined with 1.2 g of crude material prepared in the same fashion (using 0.5 g of starting material). The combined material was purified by flash chromatography on a silica gel column (49 g, eluted with 0.5% diethylamine: 1% methanol:98.5% dichloromethane, 1 L). The fractions containing the pure product were pooled and concentrated down to a light oil (3.68 g). This oil was treated with fumaric acid (1.14 g, 9.8 mmol) in ethanol (13 ml). The 6-fluoro-3-[1-[3-(2-methoxyphenoxy)-propyl]-4-piperidinyl]-1,2-benzisoxazole fumarate crystals obtained weighed 4.01 g (60%), m.p.=169°-170° C.

Fuente