Reacción #83849

Ecuación de reacción

6-fluoro-3-(4-piperidinyl)-1,2 benzisoxazole hydrochloride

K2CO3

1-[4-(3-chloropropoxy)-3-methoxyphenyl]-ethanone

dimethylformamide

→

1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-propoxy]-3-methoxyphenyl]-ethanone

Rendimiento 58.6%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe aqueous mixture was extracted with ethyl acetate
2. 2
   LavadoThe ethyl acetate was washed (water)
3. 3
   Secadodried (MgSO4)
4. 4
   Concentraciónconcentrated
5. 5
   Otroto afford a moist solid
6. 6
   OtroRecrystallization (twice) from ethyl alcohol

Procedimiento

A stirred mixture of 6-fluoro-3-(4-piperidinyl)-1,2 benzisoxazole hydrochloride (5.1 g, 20 mmol), K2CO3 (5.2 g, 40 mmol), 1-[4-(3-chloropropoxy)-3-methoxyphenyl]-ethanone (5.3 g, 22 mmol), and dimethylformamide (60 ml) was heated at 90° C. for 16 hours. The reaction was poured into water, and the aqueous mixture was extracted with ethyl acetate. The ethyl acetate was washed (water), dried (MgSO4) and concentrated to afford a moist solid. Recrystallization (twice) from ethyl alcohol afforded 5.0 g (58%) of 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-propoxy]-3-methoxyphenyl]-ethanone as a beige solid, m.p.=118°-120° C.

Fuente