Reacción #83638

Ecuación de reacción

1-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1H-pyrazol-3-ylamine

acetic anhydride

→

formamide

N-[1-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-1H-pyrazol-3-yl]formamide

Disolventes

formic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled in an ice bath
2. 2
   Otrothe solvents are evaporated off under vacuum
3. 3
   OtroThe white solid obtained
4. 4
   Filtraciónis filtered off
5. 5
   Lavadowashed with isopropyl ether
6. 6
   Otrodried under vacuum

Procedimiento

0.50 g of 1-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1H-pyrazol-3-ylamine, obtained in the previous Example, is added in small portions to a mixture of 4 ml of formic acid and 0.5 ml of acetic anhydride, cooled in an ice bath. After stirring for 30 min, the solvents are evaporated off under vacuum and the residue is taken up in isopropyl ether. The white solid obtained is filtered off, washed with isopropyl ether and dried under vacuum to give 0.49 g of the expected formamide.

Fuente