Reacción #83626

Ecuación de reacción

(-)(2aR,4S)-6-(5-oxazolyl)-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

→

title compound

Rendimiento 34.4%

(-)(4R)-6-(5-oxazolyl)-4-(di-n-propylamino)-1,3,4,5-tetrahvdrobenz[cd]indole

Rendimiento 34.4%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe oxidant was removed by filtration through celite
2. 2
   OtroThe crude product obtained
3. 3
   Filtraciónafter filtering
4. 4
   Otroremoving the solvent
5. 5
   Otrowas purified by flash chromatography

Procedimiento

A mixture of (-)(2aR,4S)-6-(5-oxazolyl)-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole (300 mg, 0.9 mmol) and 0.5 g of MnO2 in 50 ml of methylene chloride was stirred at room temperature for 16 hours. The oxidant was removed by filtration through celite. The crude product obtained after filtering and removing the solvent was purified by flash chromatography, using ethyl acetate as eluent, to provide 100 mg of title compound. Recrystallization from hexane gave 60 mg of pure title compound.

Fuente