Reacción #83404

Ecuación de reacción

meta-trifluoromethylphenol

sodium hydride

2-chloro-4-methyl-6-(3-thienylmethyloxy)pyridine

→

4-methyl-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere successively added

Procedimiento

To a solution containing meta-trifluoromethylphenol (1.70 g, 0.0021×5.0 mol) and sodium hydride (0.42 g, (ca.60% in mineral oil), 0.0021×5.0 mol) in dimethylformamide, 2-chloro-4-methyl-6-(3-thienylmethyloxy)pyridine (0.5 g, 0.0021 mol) and CuI (0.20 g, 0.0021×0.5 mol) were successively added and the resultant solution was refluxed for about 5 hours.

Fuente