Reacción #83399

Ecuación de reacción

meta-trifluoromethylphenol

sodium hydride

2-chloro-6-(3-thienylmethyloxy)pyridine

→

2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added

Procedimiento

To a solution containing meta-trifluoromethylphenol (3.62 g, 0.0045×5.0 mol), sodium hydride (0.89 g, (Ca.60% in mineral oil), 0.0045×5.0 mol) and CuI (0.42 g, 0.0045×0.5 mol) in dimethylformamide, 2-chloro-6-(3-thienylmethyloxy)pyridine (1.0 g, 0.0045 mol) was added and the resultant solution was refluxed for about 3 hours.

Fuente