Reacción #833566

Ecuación de reacción

water

1-(but-2-ynyl)-2-chloro-5-cyanomethyl-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione

potassium carbonate

(R)-3-tert-butoxycarbonylaminopiperidine

→

(R)-1-(but-2-ynyl)-2-(3-tert-butoxycarbonylamino-piperidin-1-yl)-5-cyanomethyl-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione

Disolventes

dimethylsulphoxide

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe mixture is extracted three times with ethyl acetate
2. 2
   SecadoThe combined organic phases are dried over sodium sulphate
3. 3
   Otrothe solvent is removed
4. 4
   OtroThe residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 1:1)

Procedimiento

A solution of 0.14 g 1-(but-2-ynyl)-2-chloro-5-cyanomethyl-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione, 0.15 g potassium carbonate and 0.07 g (R)-3-tert-butoxycarbonylaminopiperidine in 2 ml dimethylsulphoxide is stirred for 5 h at 60° C. Then water is added and the mixture is extracted three times with ethyl acetate. The combined organic phases are dried over sodium sulphate, and then the solvent is removed. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 1:1).

Fuente