Reacción #833550

Ecuación de reacción

4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate

NaI

→

4.5-dimethoxy-2-nitrobenzyl 2-iodoacetate

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónmixture was filtered
2. 2
   Otroevaporated
3. 3
   Otropurified by chromatography (Si-gel, CH2Cl2)

Procedimiento

A 4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate (100 mg, 0.3 mmol) was dissolved in acetone (2 ml) and NaI (50 mg, 0.33 mmol) was added. After stirring for two hours at room temperature, mixture was filtered, evaporated and purified by chromatography (Si-gel, CH2Cl2) to yield 4.5-dimethoxy-2-nitrobenzyl 2-iodoacetate (compound E (see FIG. 12c): P6—C1[X═I]) (97 mg, 85%).

Fuente