Reacción #833516

Ecuación de reacción

3-Bromo-4-(2-propenyloxy)benzaldehyde

sodium hydroxide

mesitylene

→

3-allyl-5-bromo-4-hydroxybenzaldehyde

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   LavadoThe aqueous phase was washed two times with diethyl ether
3. 3
   Extracciónextracted with ethyl acetate
4. 4
   OtroAfter drying
5. 5
   Concentraciónconcentrating the organic phase
6. 6
   Otrocrystallized
7. 7
   Temperaturaon cooling

Procedimiento

3-Bromo-4-(2-propenyloxy)benzaldehyde (20.0 g, 0.083 mol) was heated under reflux in 75 ml mesitylene (1,3,5-trimethylbenzene) for 20 hours. After cooling, 250 ml 2N sodium hydroxide were added to the reaction mixture. The aqueous phase was washed two times with diethyl ether. The aqueous phase was subsequently acidified with concentrated hydrochloric acid under ice cooling and then extracted with ethyl acetate. After drying and concentrating the organic phase, there remained an oil that crystallized on cooling.

Fuente