Reacción #832779

Ecuación de reacción

potassium carbonate

indoline-2-carboxylic acid methyl ester

3-acetylthiopropanoyl chloride

→

1-(3-acetylthiopropanoyl)-indoline-2-carboxylic acid methyl ester

Disolventes

methylene chloride

methylene chloride

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONare added at room temperature
2. 2
   Lavadowashed with 50 ml of water, 50 ml of 1N hydrochloric acid and 50 ml of saturated aqueous sodium bicarbonate
3. 3
   OtroThe organic layer is dried
4. 4
   Otroevaporated

Procedimiento

To the mixture of 7.8 g of powdered potassium carbonate, 5.0 g of indoline-2-carboxylic acid methyl ester and 50 ml of methylene chloride, 4.7 g of 3-acetylthiopropanoyl chloride [Helv. Chim. Acta 40, 2148 (1957)] in 10 ml of methylene chloride are added at room temperature. After 1 hour the mixture is diluted with 100 ml of methylene chloride and washed with 50 ml of water, 50 ml of 1N hydrochloric acid and 50 ml of saturated aqueous sodium bicarbonate. The organic layer is dried and evaporated, to give the 1-(3-acetylthiopropanoyl)-indoline-2-carboxylic acid methyl ester as an oil, showing IR-bands at 1710, 1690 and 1640 cm-1.

Fuente