Reacción #832778

Ecuación de reacción

indoline-2-carboxylic acid methyl ester

potassium carbonate

3-acetylthio-2-methylpropanoyl chloride

→

1-(3-acetylthio-2-methylpropanoyl)-indoline-2-carboxylic acid methyl ester

Disolventes

methylene chloride

methylene chloride

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with 100 ml of water, 100 ml of 1N hydrochloric acid and 100 ml of saturated aqueous sodium bicarbonate
2. 2
   OtroThe organic layer is dried
3. 3
   Otroevaporated

Procedimiento

To the stirred mixture of 5.0 g of indoline-2-carboxylic acid methyl ester [J. Am. Chem. Soc. 92, 2476 (1970)], 7.8 g of powdered potassium carbonate and 50 ml of methylene chloride, 5.1 g of 3-acetylthio-2-methylpropanoyl chloride (Belgium Pat. No. 868,532) in 20 ml of methylene chloride are added during 3 minutes at room temperature. After 2 hours the mixture is diluted with 100 ml of methylene chloride and washed with 100 ml of water, 100 ml of 1N hydrochloric acid and 100 ml of saturated aqueous sodium bicarbonate. The organic layer is dried and evaporated, to give the 1-(3-acetylthio-2-methylpropanoyl)-indoline-2-carboxylic acid methyl ester as an oil, showing in the IR-spectrum bands at 1710, 1690 and 1675 cm-1.

Fuente