Reacción #83213

Ecuación de reacción

water

4-fluorophenylacetonitrile

ethyl isonicotinate

Sodium

→

2-(4-fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe solution was refluxed for 3 hours
2. 2
   TemperaturaThe reaction mixture was cooled
3. 3
   OtroThe ethanol of the mixture was removed under reduced pressure
4. 4
   LavadoThe resulting aqueous solution was washed with ether and neutralized with diluted hydrochloric acid
5. 5
   OtroThe separated solid was collected
6. 6
   Lavadowashed with water
7. 7
   Otrodried

Procedimiento

Sodium (2.48 g) was dissolved in dry ethanol (37 ml) under nitrogen atmosphere. To the solution was added 4-fluorophenylacetonitrile (11.65 g) and ethyl isonicotinate (16.41 ml) and the solution was refluxed for 3 hours. The reaction mixture was cooled and poured into water. The ethanol of the mixture was removed under reduced pressure. The resulting aqueous solution was washed with ether and neutralized with diluted hydrochloric acid. The separated solid was collected, washed with water and dried to give 2-(4-fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile (16.43 g).

Fuente