Reacción #83182

Ecuación de reacción

alpha-(4-chlorophenyl)-alpha-ethyl-1H-1,2,4-triazole-1-propanenitrile

sodium hydroxide

→

white solid

Rendimiento 91.6%

2-(4-chlorophenyl)-2-[(1,2,4-triazol-1-yl)methyl]butyramide

Rendimiento 91.6%

Disolventes

dimethyl sulfoxide

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas consumed
2. 2
   workup.ADDITIONThe reaction was poured into water
3. 3
   Extracciónextracted with ethyl acetate
4. 4
   LavadoAfter washing with brine
5. 5
   Secadothe organic phase was dried over magnesium sulfate
6. 6
   Concentraciónconcentrated under vacuum
7. 7
   Temperaturawithout heating
8. 8
   OtroRemoval of the solvent
9. 9
   Otrogave a foamy glassy solid which
10. 10
    Otrowas triturated with hexane
11. 11
    Filtraciónfiltered

Procedimiento

To a 500 mL flask was charged 100.0 g (0.38 mole) of alpha-(4-chlorophenyl)-alpha-ethyl-1H-1,2,4-triazole-1-propanenitrile and 100 mL of dimethyl sulfoxide. To the stirring solution was added 100 g (1.25 mole) of 50% sodium hydroxide. The reaction mixture was heated at 100° C. for 1 hour after which GLC indicated the starting material was consumed. The reaction was poured into water and extracted with ethyl acetate. After washing with brine, the organic phase was dried over magnesium sulfate and concentrated under vacuum without heating. Removal of the solvent gave a foamy glassy solid which was triturated with hexane, filtered and gave 97 g (91% yield) of a white solid, melting point 139°-140° C.

Fuente