Reacción #83175

Ecuación de reacción

D-glucono1,5-lactone

tallowaminopropylamine

→

D-gluconamide

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA 1 liter round bottom flask equipped with a condenser, addition funnel
2. 2
   Otrothe heating mantle removed
3. 3
   TemperaturaThe reaction mixture was cooled
4. 4
   FiltraciónThe white product was filtered
5. 5
   Lavadowashed with cold isopropanol (3×100ml)
6. 6
   Otrodried under vacuum at 35° C.

Procedimiento

A 1 liter round bottom flask equipped with a condenser, addition funnel, thermometer and mechanical stirrer was charged with D-glucono1,5-lactone (20.0 g, 0.11 mole) and methanol (56 g). The suspension was heated to 40° C. over 15 minutes and the heating mantle removed. Hydrogenated tallowaminopropylamine (36.0 g, 0.11 mole) was added dropwise over 15 minutes with rapid stirring. The reaction mixture was cooled and placed in a refrigerator at 0° C. overnight. The white product was filtered, washed with cold isopropanol (3×100ml) and dried under vacuum at 35° C. giving 46.2 g (83% yield) of hydrogenated tallowaminopropyl D-gluconamide with a melting point of 112°-115° C.

Fuente