Reacción #83112

Ecuación de reacción

2,4-anhydro-3,5-bis-O-(phenylmethyl)-D-lyxonic acid methyl ester

hydrogen

→

desired product

Rendimiento 96.2%

2,4-Anhydro-D-lyxonic Acid Methyl Ester

Rendimiento 96.2%

Disolventes

methyl alcohol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture is filtered through diatomaceous earth
2. 2
   Lavadowashed with ethyl acetate and ethyl alcohol
3. 3
   Concentraciónconcentrated in vacuo

Procedimiento

A slurry of 1.01 g of 2,4-anhydro-3,5-bis-O-(phenylmethyl)-D-lyxonic acid methyl ester (prepared by the procedure in Tetrahedron Letters, Vol 31, No. 33, p4787, 1990), 0.253 g of palladium hydroxide on carbon, and 30 ml of methyl alcohol is hydrogenated under a balloon of hydrogen (1 atm.) for 2.5 hours. The mixture is filtered through diatomaceous earth, washed with ethyl acetate and ethyl alcohol, and concentrated in vacuo to give 0.460 g of the desired product.

Fuente