Reacción #83086

Ecuación de reacción

trifluoromethanesulfonic anhydride

product

1,4-Anhydro-2-deoxy-D-erythro-pentitol

pyridine

→

desired product

1,4-Anhydro-2-deoxy-D-erythro-pentitol 5-(Trifluoromethanesulfonate)

Disolventes

methylene chloride

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe temperature is maintained below -10° C. during the addition
2. 2
   FiltraciónThe reaction is filtered
3. 3
   Concentraciónthe filtrate concentrated in vacuo to an oily residue
4. 4
   OtroThe residue is purified by chromatography (silica gel: 50% ethyl acetate/hexane)

Procedimiento

To a -20° C. solution, under argon, of 8.4 ml of trifluoromethanesulfonic anhydride in 75 ml of methylene chloride is added, dropwise, a solution of 5.9 g of product from Example 268 and 4.05 ml of pyridine in 25 ml of methylene chloride. The temperature is maintained below -10° C. during the addition. The progress of the reaction is monitored by tic. The reaction is filtered and the filtrate concentrated in vacuo to an oily residue, The residue is purified by chromatography (silica gel: 50% ethyl acetate/hexane) to give 7.03 g of the desired product.

Fuente